A1 and A3 ARs |
A1 and A3 subtype adenosine receptors |
AH |
aqueous humor |
AQP1 and AQP4 |
aquaporin−1 and −4 water channels |
BAF |
bafilomycin A1 (inhibitor of vesicular ATP release) |
bCE |
bovine ciliary epithelial cell |
CD73 |
ecto-5′-nucleotidase |
CE |
ciliary epithelial cell |
CFTR |
cystic fibrosis transmembrane conductance regulator CI− channel |
Cx |
connexin hemichannel or gap junction |
DTT |
dithiothreitol (a reducing agent partially blocking PX1) |
E-NPP1-3 |
ecto-nucleotide pyrophosphatases/phosphodiesterases 1-3 |
E-NTPD2, E-NTPD8 |
ecto-nucleoside triphosphate diphosphohydrolases 2 and 8 |
FGF |
fibroblast growth factor |
GM6001 |
non-selective inhibitor of metalloproteinase activity |
HCE |
immortalized human nonpigmented ciliary epithelial cell |
HEK293T |
human embryonic kidney 293 cell line containing the SV40 large T-antigen |
HEP |
heptanol (relatively selective Cx inhibitor at 1 mM) |
ICl,swell
|
swelling-activated CI− current |
IOP |
intraocular pressure |
KN-62 |
inhibitor of P2X7
|
MMP |
matrix metalloproteinase |
NPE |
nonpigmented ciliary epithelial cell or cell layer |
P2X7
|
P2X7 subtype ATP receptor |
PX1 |
pannexin-1 hemichannel |
PE |
pigmented ciliary epithelial cell or cell layer |
PRO |
probenecid (inhibitor of PX1 hemichannels) |
Pxs |
pannexins |
RT-PCR |
reverse-transcription polymerase chain reaction |
TM |
trabecular meshwork |
TM5 |
transformed human trabecular meshwork cell line |