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. Author manuscript; available in PMC: 2012 Jun 4.
Published in final edited form as: Exp Gerontol. 2006 Jul 13;41(8):718–726. doi: 10.1016/j.exger.2006.06.003

Fig. 4.

Fig. 4

Nampt (PBEF/Visfatin) as a regulator of cell survival, metabolism and longevity. In this model, Nampt is upregulated by nutrient deprivation, caloric restriction (CR) and other forms of mild stress, and localizes with Nmnat to various organelles to catalyze NAM depletion and NAD+ production. This stimulates sirtuins, PARP and other NAD+ dependent enzymes that boost cell survival and alter metabolism to promote the survival of mammals during adversity. Nampt is also secreted from adipocytes as Visfatin and it bind to the insulin receptor to trigger glucose uptake by peripheral tissues. Prolonged upregulation of Nampt might mimic aspects of CR and extend mammalian lifespan, as PNC1 does in S. cerevisiae.