Fig. 4.

A–W Facial appearance of patients with an EHMT1 mutation. Patient 17 at age 2 years (A, B), patient 18 at age 1 year (C) and 6 years (D, E), patient 19 at age 3 years (F, G), patient 20 at age 41 years (H, I), patient 21 at age 5 years (J, K), patient 24 at age 2 years (L, M) and 10 years (N), patient 25 at childhood age (O), during teenage (P), and age 32 years (Q, R), patient 26 at age 2 years (S) and age 10 years (T, U), patient 27 at age 11 years (V, W). Facial characteristics are similar to Kleefstra syndrome patients with a 9q34.3 deletion.