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. 2012 Apr 16;122(5):1849–1868. doi: 10.1172/JCI59218

Figure 11. PC-3/S cells facilitate the spread and metastatic growth of PC-3/Mc cells.

Figure 11

(A) Orthotopic coimplantation of GFP-PC-3/Mc cells with RFP- and Renilla luciferase–expressing PC-3/S cells in the ventral prostate of NOD-SCID mice diminished their growth rate at the implantation, while accelerating the appearance of metastatic growth. Bioluminescence monitoring was performed separately for the anterior and posterior halves of the mice, for improved resolution. Middle: growth curves of orthotopically implanted tumor cells, with photon counts normalized relative to values on day 0. Right: Kaplan-Meier actuarial plots for metastasis-free mice. (B) Coimplantation (i.m.) of GFP-PC-3/Mc cells with RFP-PC-3/S cells diminished their growth rate as compared with GFP-PC-3/Mc cells implanted alone. Bottom: graphical representation of growth at the implantation site. (C) Coinoculation (i.v.) of GFP-PC-3/Mc cells with RFP-PC-3/S cells accelerated their lung colonization. Bottom: Kaplan-Meier actuarial plots for lung colony–free mice. (D) Coinoculation (i.c.) of GFP-PC-3/Mc cells with RFP-PC-3/S cells did not significantly affect their bone colonization efficiency. Right panel: Kaplan-Meier actuarial plots for bone colony–free mice. Results are expressed as mean ± SEM.