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. Author manuscript; available in PMC: 2013 May 8.
Published in final edited form as: Biochemistry. 2012 Apr 23;51(18):3732–3743. doi: 10.1021/bi201420a

Figure 3.

Figure 3

(a) Na+-dependent kinetics for the formation of the GAAA tetraloop–receptor interaction. An increasing Na+ concentration yields a significant enhancement of the folding rate constant (kfold) and a subtle reduction in the rate constant for the unfolding process (kunfold). (b) Dependence of the free energy on Na+ concentration. (c) Preferential interaction coefficient analysis for the formation of the tertiary interaction, which yields an ion pair uptake (2ΔΓ ±) of 2.4(1) and no change in free energy at 170(20) mM Na+.