FIGURE 1.

ClustalW2 multiple amino acid sequence alignment of copper-sensing CsoR proteins for which biochemical or structural data have been reported. Completely and partially conserved residues are boxed in dark and light gray, respectively. The conserved Cu(I)-binding ligands are indicated (*) along with residues reported to play a role in the Cu(I)-binding allosteric regulation of DNA (+). The UniprotKB accession numbers are Q8Y646 (L. monocytogenes), A6QIT1 (S. aureus), O32222 (B. subtilis), and P71543 (M. tuberculosis).