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Effect of GITR ligation on suppression of in vitro proliferation of activated CD4CD25− T cell in the presence and absence of JNKi (50 μm). A, GITRL stimulation abrogates suppression of CD4+CD25− T cell proliferation, and treatment of nTregs with JNKi restores suppression. B, absence of carboxyfluorescein diacetate succinimidyl ester dilution in GITR-stimulated CD4+CD25+ T cells. The means ± S.E. from three independent experiments were carried out in triplicate. *, p < 0.05.
