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. 2012 Apr 2;287(21):17426–17437. doi: 10.1074/jbc.M112.359950

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Fenretinide reduces muscle and liver ceramides and increases dihydroceramides. Lipids from soleus (Sol.) and liver (Hep.) were extracted from tissues of mice receiving SD, HFD, or HFD with fenretinide (HFD+FEN) after 4 weeks of treatment. A–D, in both soleus (A and B) and liver (C and D), the HFD-induced increase in ceramides was prevented with FEN treatment (A and C). Moreover, FEN increased dihydroceramides in both tissues (B and D). *, p < 0.05 for treatment versus SD. +, p < 0.05 for HFD+FEN versus HFD (n = 6).