. 2012 Mar 27;287(21):17777–17788. doi: 10.1074/jbc.M112.354274

TABLE 1.

Genes that were differentially expressed in enterocytes of WT and IE-Cpr-null mice

Genes with significantly different expression (p ≤ 0.01), and with at least a 75% difference between the IE-Cpr-null and WT mice (i.e. with fold change ≥1.75 or ≤0.57), in at least one probe set, are shown. For genes represented by multiple probe sets, the results for all probe sets are included, although all probe sets may not meet the selection criteria. For each entry, a reference sequence transcript identification number (RefSeq transcript ID) is given, along with the gene symbol and gene name (according to Affymetrix). The genes selected are grouped according to functional categories (defined in GenMAPP or UniProt or through a literature search).

Gene symbol	Ref Seq transcript ID	Fold change (IE-Cpr-null/WT)	Gene name
Biotransformation
Adh4	NM_011996	0.53	Alcohol dehydrogenase 4
Akr1c14	NM_134072	0.47	Aldo-keto reductase family 1, member C14
Cyp1a1	NM_001136059	3.8	Cytochrome P450 1a1
Cyp1a2	NM_009993	44	Cytochrome P450 1a2
Cyp51	NM_020010	2.4/1.9/1.0	Cytochrome P450 51
Por	NM_008898	0.56	Cytochrome P450 oxidoreductase

Lipid metabolism
Acer1	NM_175731	2.4	Alkaline ceramidase 1
Fdft1	NM_010191	1.9/1.7	Farnesyl diphosphate farnesyl transferase 1
Idi1	NM_145360	2.0/1.5	Isopentenyl-diphosphate δ isomerase
Lss	NM_146006	2.0^a/1.8/1.0^a	Lanosterol synthase
Mvd	NM_138656	2.7/2.4	Mevalonate (diphospho) decarboxylase
Pla2g7	NM_013737	0.24	Phospholipase A2, group VII
Pmvk	NM_026784	1.9	Phosphomevalonate kinase
Pnpla7	NM_146251	2.4	Patatin-like phospholipase domain containing 7
Scd2	NM_009128	7.1/3.4	Stearoyl-coenzyme A desaturase 2
Sqle	NM_009270	2.5	Squalene epoxidase

Growth factors
Btc	NM_007568	0.76^a/0.47	Betacellulin, EGF family member
Caprin2	NM_181541	0.43	Caprin family member 2
Ereg	NM_007950	1.9	Epiregulin
Nrg4	NM_032002	0.41	Neuregulin 4

Transporters
mfsd7c/Flvcr2	NM_145447	6.2	Major facilitator superfamily domain-containing 7C
Slc23a2	NM_018824	0.54/0.43	Solute carrier family 23, member 2

Antigen processing and presentation
Ciita	NM_007575	4.5/4.4	Class II transactivator
H2-Aa	NM_010378	3.0/2.2^b	Histocompatibility 2, class II antigen A, α
H2-Ab1	NM_207105	2.3/2.1/1.9	Histocompatibility 2, class II antigen A, β1
H2-Dma	NM_010386	2.3	Histocompatibility 2, class II, locus DMa
H2-Dmb1/Dmb2	NM_010387/NM_010388	2.9/3.3	Histocompatibility 2, class II, locus DMb1/2
H2-Eb1	NM_010382	1.9	Histocompatibility 2, class II antigen E β
H2-gs10	NM_001143689	1.8	MHC class I like protein GS10
0610037M15Rik	XM_903697	1.8	RIKEN cDNA 0610037M15 gene

Other
6330442E10Rik	NM_178745	0.34	RIKEN cDNA 6330442E10 gene
Acta1	NM_009606	4.1	Actin, α1, skeletal muscle
Apcdd1	NM_133237	1.0^a/0.86^a/0.79^b/0.48	APC-down-regulated 1
Gbp2	NM_010260	2.2^b/2.1	Guanylate nucleotide-binding protein 2
Gm7120	NM_001039244	1.0^a/0.49	Predicted gene 7120
Gphn	NM_172952	0.61^b/0.47	Gephyrin
Greb1	NM_015764	0.28	Gene regulated by estrogen in breast cancer protein 1
Hlf	NM_172563	0.88^a/0.31	Hepatic leukemia factor
Jdp2	NM_030887	2.1	Jun dimerization protein 2
Map3k6	NM_016693	2.6	MAP kinase kinase kinase 6
Mt1	NM_013602	160/8.0	Metallothionein 1
Mup1	NM_001045550	440/8.0^a	Major urinary protein1 (and 2/7/8/10/12/17)
Pdk4	NM_013743	0.32	Pyruvate dehydrogenase kinase isoform 4
Pfkfb3	NM_133232	1.9/1.5^a	6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Rps6ka2	NM_011299	1.0^a/0.57	Ribosomal protein S6 kinase, polypeptide 2
Secisbp2l	NM_177608	1.8/1.2^a	SECIS binding protein 2-like
Susd2	NM_001162913	1.9	Sushi domain-containing 2
Tmem184c	NM_145599	2.5	Transmembrane protein 184c
Tmigd1	NM_025655	4.2	Transmembrane and immunoglobulin domain-containing 1
Tubb2b	NM_023716	0.54	Tubulin, β2b
Ubd	NM_023137	7.5	Ubiquitin D

^a p > 0.05.

^b 0.01 ≤ p ≤ 0.05.