Table 1.
Clinical and laboratory features of children dying from cerebral malaria due to mixed Plasmodium falciparum/Plasmodium vivax infections
| Patient 1 | Patient 2 | Patient 3 | |
|---|---|---|---|
| Age (months) | 63 | 36 | 94 |
| Sex | Female | Female | Male |
| Blantyre coma score on admission | 0 | 2 | 1 |
| Blood lactate (mmol/L) | 1.6 | 6.4 | 1.0 |
| Plasma bicarbonate (mmol/L) | 18 | 10.2 | 22.3 |
| Blood glucose (mmol/L) | 18.4 | 3.2 | 7.0 |
| Haemoglobin (g/L) | 69 | 39 | 111 |
| Peripheral parasitaemia (/μL) by light microscopy: | |||
| P. falciparum | 154,000 | 104,000 | 0 |
| P. vivax | 0 | 80 | 0 |
| Plasmodium species by nPCR (blood) | Mixed species | Mixed species | Mixed species |
| Peripheral parasitaemia by qPCR (number of cycles): | |||
| P. falciparum | 26.3 | 23.1 | 37.2 |
| P. vivax | 41.0 | 29.2 | 35.8 |
| Plasmodium species by nPCR (brain) | P. falciparum | P. falciparum | Negative |