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. 2012 Jun 4;7(6):e38367. doi: 10.1371/journal.pone.0038367

Figure 1. Experimental design for detecting host transcriptional responses to different Mtb W-Beijing strains.

Figure 1

Genetic diversity of W-Beijing family strains, as revealed by SNPs-based genotyping (see our recent work [16] for details). In brief, 48 SNPs were characterized by sequencing 22 genes (being involved in DNA repair, replication, and recombination) in 58 W-Beijing isolates plus one non-W-Beijing isolate (Myc2). Each node represents one genotype (the same SNPs profile), with the node area proportional to the population size (the number of W-Beijing isolates in it was indicated on the left). Strains from the corresponding node used for the THP-1 infection in this study (e.g., R1.4 from Bmyc10) were indicated on the right. Lab strain H37Rv, which was also recruited for the THP-1 infection, was not shown here.