Table 1. Biodistribution of 99mTc-ni3A in mice.
| t = 3 hr | t = 6 hr | t = 24 hr | ||||
| Tissue/organ | Wildtypes | APP/PS1 | Wildtypes | APP/PS1 | Wildtypes | APP/PS1 |
| blood | 1.202±0.379 | 1.146±0.131 | 0.778±0.048 | 0.808±0.115 | 0.451±0.073 | 0.363±0.051 |
| heart | 0.525±0.129 | 0.508±0.109 | 0.347±0.049 | 0.337±0.127 | 0.252±0.041 | 0.216±0.014 |
| lungs | 0.850±0.184 | 0.819±0.208 | 0.659±0.184 | 0.743±0.301 | 0.375±0.113 | 0.291±0.055 |
| liver | 1.078±0.235 | 1.000±0.293 | 1.078±0.188 | 1.223±0.424 | 0.568±0.149 | 0.488±0.164 |
| kidneys | 15.531±2.986 | 15.192±3.075 | 10.266±1.657 | 14.294±4.337 | 9.089±6.152 | 9.901±1.158 |
| spleen | 0.590±0.257 | 0.531±0.084 | 0.792±0.144 | 0.753±0.291 | 0.397±0.056 | 0.465±0.234 |
| muscle | 0.171±0.075 | 0.120±0.069 | 0.111±0.088 | 0.086±0.022 | 0.043±0.007 | 0.048±0.008 |
| cerebrum | 0.035±0.009 | 0.035±0.007 | 0.031±0.007 | 0.035±0.008 | 0.018±0.003 | 0.019±0.001 |
| cerebellum | 0.073±0.031 | 0.063±0.009 | 0.098±0.009 | 0.096±0.014 | 0.029±0.005 | 0.026±0.002 |
| cerebrum/blood ratio | 0.030±0.003 | 0.030±0.004 | 0.040±0.010 | 0.043±0.004 | 0.040±0.001 | 0.053±0.008 * |
| cerebrum/muscle ratio | 0.242±0.142 | 0.335±0.116 | 0.407±0.270 | 0.428±0.171 | 0.422±0.029 | 0.403±0.100 |
*
= P<0.05 wildtype mice compared to APP/PS1 mice.
A bolus injection of 2 µg 99mTc-ni3A was administered intravenously into 12–14 month old APP/PS1 mice or their wild type littermates. At three time points after injection the animals were sacrificed and various tissues and entire organs were removed, weighed and counted for radioactivity. Values are expressed as a percentage of the injected dose per gram tissue (mean ± SD).