Table 4. Blood distribution of 99mTc-pa2H.
Sample | Time p.i. | Fraction | APP/PS1 | Wildtype | ||
(min) | (%) | sd | (%) | sd | ||
99mTc-pa2H | 10 | Plasma | 88,9 | 6,2 | 80,3 | 5,2 |
Cell Pellet | 11,1 | 19,7 | ||||
90 | Plasma | 83,6 | 8,7 | 72,0 | 8,2 | |
Cell Pellet | 16,4 | 28,0 |
At different time point after bolus injection of 99mTc-pa2H blood collected from the tail vein of 12–14 month old APP/PS1 mice or wildtype littermates. Separated into the cell pellet and plasma, samples were counted for radioactivity. Fractions are expressed in percentage of total activity at that time point. No significant differences were calculated using a student t-test (p<0.05).