Figure 3. Maternal BPA exposure alters the tissue pathology following influenza A virus infection.

Adult offspring of treated dams were infected with influenza virus (HKx31). To examine lung pathology, sub-groups of infected mice were sacrificed 3, 7 or 10 days following infection and lungs were fixed in-situ with 10% neutral buffered saline. Paraffin embedded tissues were cut in 5 µM think sections and stained with H&E. (A) Representative images of tissue sections from infected female mice are depicted. All images are at the same magnification. (B) Tissue sections from all mice in each group were scored based on the degree of inflammatory cell accumulation, as outlined in the Material and Methods section. Data in the graphs represent mean ± SEM (n = 5/group/time point); *p≤0.05.