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. 2012 Jun 4;7(6):e38018. doi: 10.1371/journal.pone.0038018

Figure 4. CA1 synapses in the aging hippocampus retain responsiveness to E2 after long-term hormone deprivation.

Figure 4

Evoked fEPSPs were measured in acute hippocampal slices from aged (15–18 mo, 6 months after OVX) and young (2 mo, 7–10 days after OVX) females. E2 (1 nM) was bath applied after 15 min stable baseline. Panel A: E2 facilitated fEPSPs in young (open circles) and aged (black circles) females with short latency. Panel B: Representative fEPSPs from young (n = 7 slices from 6 rats) and aged (n = 5 slices from 4 rats) rats before and after E2 application. Panel C: The averaged responses for the last 5 min baseline recording and the averaged responses during 25–30 min after the start of E2 application. Data are means ± SEM. n.s., not significant. **, p<0.01.