Table 3. Summary of results from 15 monkeys.
Summary of each monkey’s MPTP dose, age at MPTP injection, Parkinsonism score, apathy score, cell counts, and DTBZ, CFT, and FD specific striatal uptake. MPTP dose is given in mg/kg and motor score is the final score at 2 months post-MPTP. Apathy ratio is the post/pre-MPTP ratio; specific tracer uptake ratio in NAcc is the injected/control side ratio post-MPTP, with BP values used for DTBZ and CFT and Kocc used for FD; VTA count ratio is the injected/control side ratio of cell counts.
| Monkey number | Age | MPTP dose | Motor Score | Apathy | NAcc Specific Uptake | VTA | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Pre- MPTP | Post- MPTP | Ratio | DTBZ Ratio | CFT Ratio | FD Ratio | Count Ratio | ||||
| 1a | 5.8 | 0 | 0 | 10 | 8.4 | 0.84 | 1.01 | 0.91 | 1.05 | 0.94 |
| 2 | 5.6 | 0 | 0 | 9 | 7.8 | 0.87 | 0.99 | 0.99 | 1.01 | 0.90 |
| 3 | 5.6 | 0.07 | 3 | 10.4 | 11.1 | 1.07 | 0.73 | 0.49 | 0.74 | 0.90 |
| 4a | 3.5 | 0.08 | 3 | 7 | 8.2 | 1.17 | 0.66 | 0.66 | 0.75 | 0.64 |
| 5a | 3.7 | 0.12 | 3 | 7.4 | 6.2 | 0.84 | 0.77 | 0.59 | 0.90 | 0.74 |
| 6 | 5.3 | 0.13 | 2 | 6.8 | 7.2 | 1.05 | 0.96 | 0.96 | 1.06 | 0.98 |
| 7 | 4.5 | 0.13 | 0 | 8.8 | 10.2 | 1.16 | 0.89 | 0.90 | 0.87 | 0.86 |
| 8 | 6.3 | 0.13 | 6 | 8.4 | 11.2 | 1.33 | 0.59 | 0.24 | 0.33 | 0.61 |
| 9 | 6.3 | 0.14 | 8 | 9.6 | 14.6 | 1.52 | 0.31 | 0.20 | 0.64 | 0.61 |
| 10 | 6.4 | 0.14 | 4 | 8.2 | 9.6 | 1.17 | 0.92 | 0.90 | 0.90 | 0.84 |
| 11 | 6.4 | 0.14 | 5 | 8.4 | 13.6 | 1.62 | 0.62 | 0.18 | 0.59 | 0.58 |
| 12 | 5.1 | 0.19 | 6 | 10.4 | 13.7 | 1.32 | 0.50 | 0.22 | 0.64 | -- |
| 13a | 4.1 | 0.20 | 7 | 7 | 9.8 | 1.40 | 0.46 | 0.35 | 0.41 | 0.56 |
| 14a | 5.5 | 0.24 | 6 | 6.67 | 10 | 1.50 | 0.28 | 0.21 | 0.51 | 0.64 |
| 15 | 5.6 | 0.31 | 7 | 7.6 | 10.8 | 1.42 | 0.27 | 0.15 | 0.40 | 0.70 |
M. nemenstrina