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. Author manuscript; available in PMC: 2012 Jun 5.
Published in final edited form as: Neurotoxicol Teratol. 2012 Mar 7;34(3):311–322. doi: 10.1016/j.ntt.2012.02.003

Fig. 5. Fear conditioning.

Fig. 5

(A) Mice were trained to associate the context (the test environment) and the cue (an auditory tone) with a mild foot shock administered, along with the cue, 3 times over a 6-minute training period. The percentage of time spent freezing was recorded for each minute of testing. B) The following day, mice were returned to the testing chamber to measure the fear response associated with the context of the testing environment. C) On the following day, mice were placed in a novel environment and after 2 min were presented with the cue, which continued for 3 min. The percent of time spent freezing was recorded for each minute of testing. Values are expressed as mean percent of time spent freezing±SE for PON1−/− mice exposed to 0.15 mg/kg/d CPO (light-gray circles), 0.18 mg/kg/d CPO (dark-gray circles), or 0.25 mg/kg/d CPO (black circles), or to vehicle alone (white circles). An additional control group (white diamonds) received the tone with no shock.