Figure 6. Effects of MMP-2 and/or -9 knockouts on brain edema and behavioral deficits after 1 h ischemia and 7 h reperfusion (n = 12 in the MMP-2 KO group; n = 13 in other groups).
Behavioral deficits were assessed using the forelimb placing test. Higher forelimb placing scores represent better improvements in function. a) cortex swelling, b) forelimb placing score (%). dKO: MMP-2/9 double knockout group. *p < 0.05, ***p < 0.001 compared with the WT ischemia-reperfusion control.