Table 3.
The effects of MMP-2 and/or -9 KOs on the average microvascular size and numbers of laminin-immunoreactive microvessels in the cortex and the striatum.
Groups | Cortex | Striatum | ||
---|---|---|---|---|
Average microvascular size (μm2/profile) | Microvascular numbers/mm2 tissue | Average microvascular size (μm2/profile) | Microvascular numbers/mm2 tissue | |
Sham | 276.4 ± 29.3 | 332.5 ± 17.0 | 281.5 ± 47.9 | 286.1 ± 11.6 |
WT | 155.2 ± 10.5## | 307.8 ± 30.7 | 134.5 ± 11.9## | 275.0 ± 25.3 |
MMP-2 KO | 185.7 ± 30.3## | 347.7 ± 47.1 | 152.9 ± 25.5## | 261.5 ± 34.3 |
MMP-9 KO | 170.0 ± 24.0## | 344.3 ± 40.2 | 149.4 ± 14.4## | 258.5 ± 28.9 |
dKO | 180.6 ± 25.7## | 356.5 ± 57.3 | 144.0 ± 21.7## | 285.8 ± 20.4 |
dKO: MMP-2/9 double knockout.
p < 0.01 compared with the sham control.