Figure 4. P-glycoprotein and BCRP increase in spinal cord and cerebral cortex homogenates of another ALS mouse model, TDP-43 (A315T).
Disease-driven increases of P-gp and Bcrp protein expression in TDP-43 (A315T) mice are specific to the spinal cord and cerebral cortex compared to the cerebellum. The band intensity of transporter expression levels were compared to loading controls (GAPDH).