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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Neurobiol Dis. 2012 Apr 11;47(2):194–200. doi: 10.1016/j.nbd.2012.03.040

Figure 5. P-gp and BCRP expression levels increase at the blood-spinal cord barrier.

Figure 5

Isolated spinal cord microvessels show a protein expression increase in the drug transporters, P-gp and Bcrp, throughout disease progression in SOD1-G93A mice (*p < 0.05). Transporter expression levels were normalized to loading controls (GAPDH) and quantifications include a minimum of three separate experiments. Data analysis was performed using two-tailed Student’s T-tests. Data are shown as mean ± SEM. Abbreviations: Pre = Presymptomatic mice at 50 days; Onset = Mice at onset of symptoms at 90 – 100 days; Symp = Symptomatic mice at 130 days.