Table I.

Associations of the 28 SNPs examined in or near STAT6 (±20kb) in 492 trios with an asthmatic child and the subset of 162 trios with a food sensitized child (at least one positive skin prick test to six major food allergens). The flanking regions around STAT6 included SNPs in two other genes, NAB2 and LRP1. SNPs were genotyped or imputed, and MaCH Rsq values. indicate imputation quality.

SNPa	SNP Type	Gene	MAFb	MaCH Rsq value	P, asthma (N=492 trios)	P, food sensitization (N=162 trios)
rs17119418	intergenic	-	0.050	0.77	0.085	0.19
rs2035545	intergenic	-	0.053	0.80	0.19	0.17
rs324010	intergenic	-	0.41	0.92	0.035	0.010
rs324020	intronic	NAB2	0.48	0.94	0.034	0.020
rs1059513c	intergenic	-	0.074	0.99	0.35	0.56
rs703817c	3′ UTR	STAT6	0.47	0.99	0.026	0.0076
rs324015c	3′ UTR	STAT6	0.31	0.99	0.28	0.084
rs3024975	intronic	STAT6	0.060	0.81	0.25	0.30
rs3024974	intronic	STAT6	0.060	0.80	0.24	0.29
rs841718c	intronic	STAT6	0.44	0.99	0.072	0.015
rs3024971	intronic	STAT6	0.029	0.88	0.077	0.10
rs10783813	intronic	STAT6	0.20	0.61	0.57	0.23
rs324011	intronic	STAT6	0.47	0.97	0.044	0.055
rs167769c	intronic	STAT6	0.47	0.99	0.044	0.029
rs324013c	intergenic	-	0.39	0.99	0.31	0.41
rs12368672	intergenic	-	0.44	0.90	0.082	0.066
rs11172106	intergenic	-	0.41	0.91	0.28	0.36
rs12298170	intergenic	-	0.41	0.88	0.27	0.31
rs12307379	intergenic	-	0.020	0.69	0.21	0.011
rs7306742	intergenic	-	0.020	0.70	0.21	0.012
rs11172113c	intronic	LRP1	0.40	0.99	0.24	0.21
rs4759044c	intronic	LRP1	0.34	0.99	0.25	0.0056
rs1385526	intronic	LRP1	0.49	0.88	0.24	0.019
rs715948c	intronic	LRP1	0.27	0.99	0.32	0.011
rs4759277	intronic	LRP1	0.41	0.97	0.44	0.066
rs1466535c	intronic	LRP1	0.43	0.99	0.17	0.0077
rs7968719	intronic	LRP1	0.41	0.76	0.18	0.11
rs7398375	intronic	LRP1	0.30	0.66	0.37	0.034

^aSNPs ordered by their position on chromosome 12.

^bMAF among the 162 food allergen sensitized children.

^cGenotyped SNPs.

SNP, single nucleotide polymorphism; MAF, minor allele frequency; UTR, untranslated region