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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Reprod Toxicol. 2012 Mar 10;34(1):22–30. doi: 10.1016/j.reprotox.2012.03.001

Figure 2.

Figure 2

Effects of oral exposure to BPA on uterine morphology and macrophage infiltration in C57BL/6 mice without overt pyometra. Shown are representative photomicrographs of uterine sections from a control female C57BL/6 mouse (Panels A1-A4) and from two different animals in the 0.3 ppm BPA treatment group without symptomatic pyometra (Panels B1-B4; C1-C4). The uteri of BPA treated animals displayed metaplasia (C1, inset) throughout the various regions of the uterus with glandular disorganization and apparent luminal epithelial hyperplasia (C1, arrowhead). Cystic endometrial hyperplasia was also observed in one uterus (C1; denoted by *). Comparison of the density of F4/80 immunopositive cells present in sections from controls (Panels A2; A4) with those from the BPA treatment groups (Panels B2; B4 and C2; C4) demonstrates increased macrophage infiltration. Scale bars for each high magnification and low magnification photomicrograph is 100 µm.