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. Author manuscript; available in PMC: 2013 Jun 4.
Published in final edited form as: Mol Pharm. 2012 May 4;9(6):1599–1611. doi: 10.1021/mp2006054

Figure 1. G7-NH2-FITC dendrimers induce P-selectin expression on platelets (A-D).

Figure 1

Platelets were treated with saline, thrombin, or 100 μg/mL of different functionalized dendrimers for 30 minutes. Thrombin induces P-selectin expression while the G6.5-COOH-FITC and G7-OH-FITC dendrimer-treated platelets express significantly less P-selectin and negatively stain for FITC, indicating no dendrimer binding. In contrast, G7-NH2-FITC treated platelets express P-selectin and stain positively for FITC, suggesting dendrimer binding. The (*) indicates significantly different than no treatment (p<0.05). The (**) indicates significantly different than G6.5-COOH-FITC and G7-OH-FITC dendrimer (p<0.05). Flow diagrams are from a single experiment and are representative of three independent experiments (A). The data represent the mean ± SEM of at least three independent experiments.