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. Author manuscript; available in PMC: 2013 Jun 4.
Published in final edited form as: Mol Pharm. 2012 May 4;9(6):1599–1611. doi: 10.1021/mp2006054

Figure 3. Human platelets release alpha granules contents in response to G7-NH2-FITC dendrimers.

Figure 3

Whole blood treated with G7-NH2-FITC dendrimers results in significant activation of platelets based on RANTES and PF4 release after thirty minutes and four hours (A,B). Purified platelets release RANTES in a dose- and time-dependent manner after treatment with G7-NH2-FITC, but not G6.5-COOH-FITC or G7-OH2-FITC (C,D). The (*) indicates significantly different compared to no treatment (p<0.05). The (**) indicates significantly different compared to G6.5-COOH-FITC and G7-OH-FITC dendrimer (p<0.05). The data represent the mean ± SEM of at least three independent experiments.