Table 4.
The risk of all-cause mortality in patients with early-stage non-small-cell lung cancer, in stage III disease, advanced disease or small-cell lung cancer estimated by crude and adjusted Cox regression models with RRs expressed as HRs
| Early-stage NSCLC (N=1828) |
Stage III disease (N=2771) |
Advanced disease or SCLC (N=10 039) |
|||||||||||||
| Crude |
Adjusted |
%* | Crude |
Adjusted |
%* | Crude |
Adjusted |
%* | |||||||
| HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | ||||
| Socioeconomic quintile | |||||||||||||||
| Q1 (affluent) | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | |||
| Q2 | 1.22 | 0.95 to 1.56 | 1.09 | 0.85 to 1.40 | 1.16 | 1.00 to 1.34 | 1.20 | 1.03 to 1.39 | 1.16 | 1.08 to 1.25 | 1.17 | 1.08 to 1.26 | |||
| Q3 | 1.25 | 0.98 to 1.60 | 1.18 | 0.93 to 1.51 | 1.15 | 0.99 to 1.33 | 1.14 | 0.99 to 1.32 | 1.16 | 1.08 to 1.25 | 1.13 | 1.05 to 1.22 | |||
| Q4 | 1.19 | 0.94 to 1.50 | 1.15 | 0.91 to 1.46 | 1.14 | 0.99 to 1.30 | 1.15 | 1.00 to 1.32 | 1.15 | 1.07 to 1.23 | 1.16 | 1.08 to 1.25 | |||
| Q5 (deprived) | 1.35 | 1.07 to 1.70 | 1.24 | 0.98 to 1.56 | – | 1.15 | 1.01 to 1.32 | 1.16 | 1.01 to 1.34 | – | 1.15 | 1.08 to 1.24 | 1.12 | 1.05 to 1.20 | – |
| Test for trend (χ2, p value) | 4.18 | 0.04 | 2.56 | 0.11 | 2.38 | 0.12 | 0.14 | 0.70 | 9.35 | <0.01 | 1.92 | 0.17 | |||
| Sex | |||||||||||||||
| Male | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | |||
| Female | 0.84 | 0.74 to 0.96 | 0.85 | 0.75 to 0.97 | – | 0.97 | 0.89 to 1.06 | 0.95 | 0.87 to 1.03 | – | 0.95 | 0.91 to 0.99 | 0.92 | 0.88 to 0.96 | – |
| Test for trend (χ2, p value) | 6.57 | 0.01 | 7.13 | <0.01 | 0.49 | 0.48 | 3.46 | 0.06 | 5.34 | 0.02 | 12.6 | <0.01 | |||
| Age at diagnosis | |||||||||||||||
| 0–59 | 1.00 | Reference | 1.00 | Reference | 5.8% | 1.00 | Reference | 1.00 | Reference | 34.6% | 1.00 | Reference | 1.00 | Reference | 13.9% |
| 60–69 | 1.41 | 1.11 to 1.80 | 1.25 | 0.98 to 1.59 | 1.15 | 1.01 to 1.32 | 1.09 | 0.95 to 1.25 | 1.14 | 1.07 to 1.22 | 1.07 | 1.00 to 1.14 | |||
| 70–79 | 2.05 | 1.64 to 2.58 | 1.54 | 1.22 to 1.95 | 1.51 | 1.33 to 1.72 | 1.29 | 1.12 to 1.47 | 1.42 | 1.33 to 1.51 | 1.15 | 1.08 to 1.22 | |||
| 80+ | 3.61 | 2.85 to 4.58 | 1.78 | 1.39 to 2.28 | 2.17 | 1.89 to 2.49 | 1.47 | 1.26 to 1.70 | 1.82 | 1.71 to 1.95 | 1.16 | 1.08 to 1.25 | |||
| Test for trend (χ2, p value) | 101.1 | <0.01 | 16.0 | <0.01 | 92.8 | <0.01 | 19.0 | <0.01 | 245.3 | <0.01 | 13.6 | <0.01 | |||
| Charlson Score | 7.3% | 17.4% | 11.0% | ||||||||||||
| 0 | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | 1.00 | Reference | |||
| 1 | 1.10 | 0.93 to 1.30 | 0.98 | 0.82 to 1.16 | 1.10 | 1.00 to 1.22 | 1.03 | 0.92 to 1.14 | 1.08 | 1.02 to 1.13 | 0.99 | 0.94 to 1.05 | |||
| 2+ | 1.35 | 1.15 to 1.59 | 1.03 | 0.87 to 1.23 | 1.32 | 1.19 to 1.47 | 1.09 | 0.97 to 1.22 | 1.22 | 1.16 to 1.29 | 1.00 | 0.95 to 1.06 | |||
| Test for trend (χ2, p value) | 13.5 | <0.01 | 0.04 | 0.84 | 30.9 | <0.01 | 3.05 | 0.08 | 58.6 | <0.01 | 0.17 | 0.90 | |||
| Resection | 0.19 | 0.16 to 0.22 | 0.21 | 0.18 to 0.25 | 42.3% | – | – | – | – | – | – | – | – | ||
| Test (χ2, p value) | 557.2 | <0.01 | 422.3 | <0.01 | – | – | – | – | – | – | – | – | |||
| Radiotherapy | – | – | – | – | – | 0.78 | 0.72 to 0.85 | 0.81 | 0.73 to 088 | 12.9% | 0.71 | 0.67 to 0.74 | 0.73 | 0.70 to 0.76 | 1.2% |
| Test (χ2, p value) | – | – | – | – | 34.1 | <0.01 | 22.4 | <0.01 | 236.8 | <0.01 | 205.3 | <0.01 | |||
| Chemotherapy | – | – | – | – | – | 0.48 | 0.44 to 0.52 | 0.54 | 0.49 to 0.59 | 18.0% | 0.42 | 0.40 to 0.44 | 0.44 | 0.42 to 0.46 | 23.4% |
| Test (χ2, p value) | – | – | – | – | 301.7 | <0.01 | 179.6 | <0.01 | 1564.7 | <0.01 | 179.6 | <0.01 | |||
*
The relative contribution for each covariate in each subgroup was calculated as follows: ((HR for SESQ5 in a model adjusted for sex − HR for SESQ5 in a model adjusted for sex + covariate)/(HR for SESQ5 in a model adjusted for sex − 1))×100.