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. 2012 Feb 16;40(11):4816–4824. doi: 10.1093/nar/gks141

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Association of oxidized Pap1 and Prr1 is required for the activation of the antioxidant, but not the drug resistance, genes. (A) In wild-type cells, oxidation of Pap1 upon H₂O₂ stress induces its nuclear accumulation and its association with Prr1. The heterodimer is then able to activate both sets of promoters, the antioxidant (trr1, srx1, ctt1) and the drug resistance (obr1, caf5, c663.08c) genes. (B) In cells defective in Pap1 export (such as cells lacking Hba1 or expressing Pap1.C523D), the transcription factor cannot be oxidized by H₂O₂, cannot associate with Prr1 and can only trigger transcription of the drug resistance genes. (C) Similarly, in cells lacking Prr1, H₂O₂-oxidized Pap1 will only be able to activate drug resistance genes.