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. 2012 Feb 16;40(11):5023–5033. doi: 10.1093/nar/gks144

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© Crown Copyright 2012.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Defining parameters for m⁵C candidate site selection using tRNA data. (A) Plot of conversion against read coverage at 28 known m⁵C sites in human tRNAs (43). The majority of the previously identified tRNA m⁵C sites had a conversion of 80% or less and read coverage of at least 10 (shaded area). (B) Dependence of the proportion of novel tRNA candidate sites in anticipated tRNA structural positions (red circles in tRNA cloverleaf cartoon) on chosen conversion cut-off. Read coverage threshold was ≥10. Colour code for dots and lines refers to mapping at different colour-space mismatch limits.