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. 2012 Feb 22;40(11):4850–4860. doi: 10.1093/nar/gks159

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Schematic showing SHP inhibition of the Dnmt1 promoter through two distinct mechanisms. Our recent study showed that SHP inhibits ERRγ transactivation of the Dnmt1 promoter. The present study identified a zinc-mediated induction of Dnmt1 which is modulated by the cross-inhibition between MTF-1 and SHP.