Figure 3.

Effects of the brain heme oxygenase (HO) activity inhibition by tin protoporphyrin (SnPP) (3 mg/kg, intravenously; 30 minutes) and of HO-1 upregulation by cobalt protoporphyrin (CoPP) (25 mg/kg, intraperitoneally; 24 hours) on seizure-evoked reactive oxygen species (ROS) production in cerebral vessels and cortical astrocytes as detected by dihydroethidium oxidation (ox-DHE) fluorescence spectroscopy (N=4 animals in each group). ^*P<0.05 compared with baseline values. ^†P<0.05 compared with corresponding saline seizure values.