Skip to main content
. 2012 Feb 29;32(6):1035–1045. doi: 10.1038/jcbfm.2012.14

Figure 5.

Figure 5

Effect of FeTMPyP on reperfusion cerebral blood flow (CBF) and acute infarct volume during mild and severe hyperglycemic (HG) stroke. Graphs showing percent infarct volume in vehicle or FeTMPyP-treated animals after mild ischemia (<68% decrease; A) and severe ischemia (>68% decrease; C). FeTMPyP was neuroprotective and decreased infarct volume after mild ischemia but was not protective after more severe ischemia. Percent reperfusion (recovery of CBF calculated from baseline CBF using laser Doppler flowmetry) after 2 hours of ischemia and 2 hours of reperfusion after mild ischemia (<68% decrease; B) and severe ischemia (>68% decrease; D). There was considerable reperfusion after mild ischemia that was not affected by FeTMPyP treatment, suggesting that the neuroprotective effect of this compound shown in panel A was independent of an effect on CBF. However, after more severe ischemia in which FeTMPyP treatment was not effective at preventing acute brain injury, there was little to no reperfusion regardless of treatment, suggesting that the lack of effect in this group may be due to prevention of the compound reaching the target tissue. **P<0.01 versus HG vehicle; ^P<0.05 versus HG FeTMPyP after mild ischemia.