Table 2. Regional estimates of V_b, K₁, λ, and rCPSa.

Voxel-SAIFb
Region	Region size (number of voxels)	Vb	K1 (mL g−1 min−1)	λ	rCPS (nmol g−1 min−1)
Whole brain	808,068±88,180	0.073±0.010	0.043±0.007	0.73±0.02	1.77±0.07
Cerebellum	75,640±6,080	0.094±0.013	0.053±0.009	0.72±0.02	2.21±0.10
Cortical
Frontal cortex	85,452±17,015	0.073±0.013	0.047±0.008	0.71±0.03	2.02±0.06
Temporal cortex	42,125±6,437	0.075±0.011	0.044±0.007	0.71±0.02	1.90±0.09
Occipital cortex	26,971±10,079	0.090±0.017	0.055±0.008	0.72±0.03	2.30±0.14
Parietal cortex	13,127±3,241	0.079±0.014	0.048±0.007	0.71±0.02	2.10±0.14
Subcortical
Thalamus	12,757±1,862	0.073±0.012	0.043±0.008	0.74±0.01	1.59±0.10
Caudate	6,038±784	0.050±0.009	0.035±0.007	0.76±0.02	1.12±0.11
Putamen	6,488±794	0.061±0.011	0.047±0.010	0.78±0.01	1.37±0.06
Hippocampus	3,709±1,080	0.088±0.014	0.034±0.006	0.69±0.03	1.68±0.19
Amygdala	3,522±516	0.069±0.012	0.031±0.004	0.68±0.03	1.60±0.12
White matter
Corona radiata	32,655±3,350	0.035±0.007	0.027±0.005	0.76±0.03	0.90±0.06
Cerebellar peduncles	9,554±1,227	0.054±0.010	0.036±0.007	0.75±0.02	1.25±0.10

ROI-SAIFc
Region	Vb	K1 (mL g−1 min−1)	λ	rCPS (nmol g−1 min−1)
Whole brain	0.074±0.011	0.045±0.007	0.75±0.03	1.58±0.10
Cerebellum	0.095±0.012	0.056±0.010	0.75±0.02	2.00±0.18
Cortical
Frontal cortex	0.070±0.013	0.048±0.009	0.74±0.03	1.76±0.05
Temporal cortex	0.076±0.012	0.043±0.007	0.72±0.02	1.75±0.12
Occipital cortex	0.085±0.016	0.057±0.008	0.75±0.03	1.99±0.12
Parietal cortex	0.074±0.014	0.050±0.007	0.74±0.03	1.87±0.25
Subcortical
Thalamus	0.070±0.012	0.044±0.008	0.77±0.02	1.39±0.05
Caudate	0.051±0.009	0.033±0.007	0.77±0.03	1.07±0.07
Putamen	0.059±0.011	0.046±0.008	0.78±0.02	1.34±0.07
Hippocampus	0.089±0.014	0.032±0.006	0.68±0.03	1.59±0.24
Amygdala	0.073±0.012	0.030±0.004	0.68±0.04	1.51±0.12
White matter
Corona radiata	0.037±0.007	0.027±0.006	0.75±0.03	0.93±0.06
Cerebellar peduncles	0.052±0.009	0.039±0.007	0.78±0.03	1.16±0.18

Mean relative differenced and correlatione
Region	Vb		K1		λ		rCPS
	mrd	R2	mrd	R2	mrd	R2	mrd	R2
Whole brain	0%	0.99	−4%	0.99	−3%	0.81	12%	0.51
Cerebellum	−1%	0.99	−5%	1.00	−4%	0.89	10%	0.81
Cortical
Frontal cortex	4%	0.99	−1%	1.00	−4%	0.88	15%	0.73
Temporal cortex	−1%	0.99	1%	0.99	−2%	0.68	9%	0.54
Occipital cortex	5%	1.00	−4%	0.99	−5%	0.97	16%	0.76
Parietal cortex	6%	0.99	−4%	0.99	−4%	0.60	12%	0.76
Subcortical
Thalamus	4%	1.00	−4%	0.99	−4%	0.85	14%	0.58
Caudate	−1%	0.96	5%	0.98	0%	0.50	5%	0.79
Putamen	3%	0.99	2%	0.99	0%	0.62	2%	0.89
Hippocampus	−2%	0.99	6%	0.99	2%	0.65	6%	0.90
Amygdala	−5%	0.99	4%	0.92	1%	0.56	6%	0.82
White matter
Corona radiata	−6%	0.98	0%	0.98	1%	0.89	−2%	0.56
Cerebellar peduncles	4%	0.98	−9%	0.99	−4%	0.87	8%	0.85

rCPS, regional rate of cerebral protein synthesis; ROI, region of interest; SAIF, spectral analysis with iterative filter; TAC, time-activity curve; V_b, fraction of volume occupied by blood.

^aValues are mean±s.d. for six subjects.

^bVoxel-SAIF estimates based on voxel TACs and optimal voxel-SAIF filter; weights based on the whole brain TAC; parameters averaged over the volume of interest.

^cROI-SAIF estimates based on the ROI TACs and optimal ROI-SAIF filter; weights based on the ROI TAC.

^dFor each region, mean relative difference (mrd) based on the percent relative difference between voxel-SAIF and ROI-SAIF estimates, averaged among subjects.

^eRegional estimate correlation, between voxel-SAIF and ROI-SAIF, indicated by Pearsons's coefficient (R²).