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. 2012 Apr 13;13(6):569–576. doi: 10.1038/embor.2012.44

Figure 3.

Figure 3

P. aeruginosa intestinal infection potentiates dissemination phenotypes. (A) Outline of the transgene induction and infection strategy. (B) Quantitated dissemination in flies fed on sucrose (suc) only, virulent (PA14) or avirulent (CF5) P. aeruginosa strain. (C,D) pucZ expression in infected (D) and uninfected (C) byn>Ras1V12 hindguts. (C′,D′) pucZ only channels of C,D. (E) Quantitated dissemination in flies co-expressing Ras1V12 and Imd following the induction scheme in A without infection. (F, G) Hindguts co-expressing Ras1V12 and Imd show stronger MMP1 expression (red), particularly in the anterior region (arrows). (F′,G′) MMP1 channels of F,G (arrowheads: migratory cells; *P<0.05, **P<0.01). DAPI, 4,6-diamidino-2-phenylindole; GFP, green fluorescent protein; MMP1, matrix metalloprotease 1.