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. Author manuscript; available in PMC: 2012 Jun 21.
Published in final edited form as: Ann Intern Med. 2011 Jun 21;154(12):806–294. doi: 10.1059/0003-4819-154-12-201106210-00008

Figure 2. Clinical characteristics of tuberous sclerosis complex with early or late penetrance.

Figure 2

The estimated frequencies of findings (0% to 100%) over time are represented by the filled areas. Patients with tuberous sclerosis complex diagnosed in childhood (dark green) typically experience onset of multiple manifestations of the disease in the first 5 years. Patients with adult penetrance (light green) do not meet clinical criteria for diagnosis in childhood and have lower frequencies of brain and skin involvement in adulthood. The substantial variations in disease severity between patients or the potential for changing disease severity over time for 1 patient are not indicated. Patients at risk for a delay in diagnosis (not shown) have childhood penetrance but minimal illness in childhood.