Appendix Table.
Features That Differed in Frequency Between Groups at the Time of Enrollment
| Feature | Childhood Diagnosis Group (n = 31) |
Delayed Diagnosis Group (n = 30) |
Adult Penetrance Group (n = 15) |
Total (n = 76) |
|---|---|---|---|---|
| Mean number of major features at enrollment (IQR) | 7.0 (6.0–8.0) | 6.5 (5.0–7.2) | 4.0 (4.0–6.0)* | 7.0 (5.0–7.0) |
| Major skin features, n (%) | ||||
| Facial angiofibromas or forehead plaque | 30 (97) | 30 (100) | 11 (71)* | 71 (93) |
| Nontraumatic ungual or periungual fibroma | 29 (94) | 25 (83) | 8 (53)† | 62 (82) |
| Hypomelanotic macules (≥3) | 27 (87) | 21 (70) | 5 (33)* | 53 (70) |
| Shagreen patch | 25 (81) | 20 (67) | 4 (27)* | 49 (64) |
IQR = interquartile range.
*
Significant difference vs. the delayed diagnosis and childhood diagnosis groups (P < 0.05).
†
Significant difference vs. the childhood diagnosis group (P < 0.005).