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Body mass and serum leptin in CON and HF mice during the FED and FAST conditions. Body mass (A) and serum leptin (B) were elevated (*p<0.05) in HF vs. CON mice during the FED and FAST periods. While fasting reduced (†p<0.05) leptin concentrations similarly between HF and CON mice, the fold reduction in body mass was ~2-fold greater in CON vs. HF mice. Values represent mean ± SEM.
