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Proposed role of the PRDM9 protein. Left: In cells containing a functional copy of PRDM9 (Wild type) the DSB formation machinery (scissors) is directed to preferred DSB sites / PRDM9 binding sites. Right: In the absence of PRDM9, the DSB formation machinery opportunistically makes breaks at PRDM9-independent H3K4me3 marks such as those at promoters and enhancers. This results in inefficient DSB repair and meiotic arrest.
