Figure 3.

TLR TIR domains are more conserved than the LRR regions. The diversity of the amino acid sequences for each of the subfamilies that contain more than eight complete sequences was analyzed as a measure of sequence entropy (Durbin et al., 1998). In the graphs shown, the light blue line indicates the average diversity over a sliding window of 10 amino acids, and the black line shows the average diversity of each of the protein domains marked on the x-axis. In each of the subfamilies, the TIR domains exhibit greater conservation than the ectodomains, and there is significant sequence variation within the LRR domains.