Table 2.
Growth of mtr and exosome gene mutant strains on MT poisons
| Drug | |||
|---|---|---|---|
| Strain | Ben | Noc | Gene Function |
| WT | + | + | NA |
| mtr1-1 | + | + | Ran GTPase GEF Rcc1 |
| mtr2-1 | − | ± | mRNA transport factor |
| mtr3-1 | − | ± | Core exosome subunit |
| mtr4-1 | − | ± | Nuclear exosome cofactor |
| mtr5-1 | ± | − | ND |
| mtr6-1 | ± | − | ND |
| mtr7-1 | ± | ± | Acetyl-CoA carboxylase |
| mtr8-1 | + | − | ND |
| mtr10-1 | ± | + | Nuclear import receptor |
| mtr11-1 | + | + | ND |
| mtr12-1 | + | + | ND |
| mtr13-1 | + | + | RNA binding protein |
| mtr14-1 | + | + | Core exosome subunit Rrp40 |
| mtr15-1 | + | + | ND |
| mtr16-1 | + | ± | ND |
| mtr17-1 | − | − | Mitotic regulator Dis3 |
| rrp4-1 | ± | ± | Core exosome subunit |
| ski6-100 | ± | + | Core exosome subunit |
| ski2Δ | + | + | Cytoplasmic exosome cofactor |
| ski3Δ | + | + | Cytoplasmic exosome cofactor |
| ski8Δ | + | + | Cytoplasmic exosome cofactor |
| rrp6Δ | + | + | Nuclear exosome subunit |
| rrp47Δ | + | ND | Nuclear exosome cofactor |
Ben, benomyl; Noc, nocodazole; ND, not determined; NA, not applicable.
Streak growth at 25°: good (+), intermediate (±), or poor (−).