Appearance of CD1 mouse retina and optic nerve pre- and post-rAION induction. A. Pre-induction (naïve retina). The optic nerve (ON) is slightly grayish/translucent, with a reddish halo of choroidal vessels (arrowheads). The choroid is visible beneath the transparent retina (Ret). B. Animal 1, 1d post-induction. The optic nerve is pale, with obscuration of the optic nerve/retina junction (arrows). There is loss of the reddish choroidal ring around the ON. C. Animal 2, 1d post-induction. There is ON pallor and obscuration of the vessels emerging from the ON (ON edema; arrows). The zone of whitening extends beyond the ON (arrowheads), with obscuration of the choroidal vasculature beneath the retina.