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. Author manuscript; available in PMC: 2012 Jun 5.
Published in final edited form as: Mol Cells. 2008 May 16;25(3):332–346.

Table 2B.

Proteins of inflammation implicated in regulation by glutathionylation

Protein Function Affect of S-glutathionylation Stimuli Milieu GRx tested Reference
IRF3 Transcription factor ↓ CBP binding, ↓ IFN production Indigenous HEK293 cells Yes Prinarakis et al. 2008
NFκB (p50) Transcription factor ↓ DNA Binding GSSG In vitro No Pineda-Molina et al. 2001
PKC Kinase ↓ Peptide phosphorylation Diamide NIH3T3 cells No Ward et al. 2000
PON-1 Esterase ↓ paraoxonase, arylesterase, and lactonase activities GSSG Evolved PON1, Human HDL-PON1 No Rozenberg & Aviram 2006
PTEN Phosphatase ↓ Phosphatase activity (speculative) ATP Alveolar Macrophages No Cruz et al. 2007
Ras G protein ↑ Protein synthesis, p38 and Akt activation, All, OxLDL, peroxynitrite Smooth muscle and Endothelial cells Yes Chevruel et al. 2006; Chevruel et al. 2006; Adachi et al. 2004