Table 2B.

Proteins of inflammation implicated in regulation by glutathionylation

Protein	Function	Affect of S-glutathionylation	Stimuli	Milieu	GRx tested	Reference
IRF3	Transcription factor	↓ CBP binding, ↓ IFN production	Indigenous	HEK293 cells	Yes	Prinarakis et al. 2008
NFκB (p50)	Transcription factor	↓ DNA Binding	GSSG	In vitro	No	Pineda-Molina et al. 2001
PKC	Kinase	↓ Peptide phosphorylation	Diamide	NIH3T3 cells	No	Ward et al. 2000
PON-1	Esterase	↓ paraoxonase, arylesterase, and lactonase activities	GSSG	Evolved PON1, Human HDL-PON1	No	Rozenberg & Aviram 2006
PTEN	Phosphatase	↓ Phosphatase activity (speculative)	ATP	Alveolar Macrophages	No	Cruz et al. 2007
Ras	G protein	↑ Protein synthesis, p38 and Akt activation,	All, OxLDL, peroxynitrite	Smooth muscle and Endothelial cells	Yes	Chevruel et al. 2006; Chevruel et al. 2006; Adachi et al. 2004