Table 2B.
Proteins of inflammation implicated in regulation by glutathionylation
Protein | Function | Affect of S-glutathionylation | Stimuli | Milieu | GRx tested | Reference |
---|---|---|---|---|---|---|
IRF3 | Transcription factor | ↓ CBP binding, ↓ IFN production | Indigenous | HEK293 cells | Yes | Prinarakis et al. 2008 |
NFκB (p50) | Transcription factor | ↓ DNA Binding | GSSG | In vitro | No | Pineda-Molina et al. 2001 |
PKC | Kinase | ↓ Peptide phosphorylation | Diamide | NIH3T3 cells | No | Ward et al. 2000 |
PON-1 | Esterase | ↓ paraoxonase, arylesterase, and lactonase activities | GSSG | Evolved PON1, Human HDL-PON1 | No | Rozenberg & Aviram 2006 |
PTEN | Phosphatase | ↓ Phosphatase activity (speculative) | ATP | Alveolar Macrophages | No | Cruz et al. 2007 |
Ras | G protein | ↑ Protein synthesis, p38 and Akt activation, | All, OxLDL, peroxynitrite | Smooth muscle and Endothelial cells | Yes | Chevruel et al. 2006; Chevruel et al. 2006; Adachi et al. 2004 |