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A model for activation of MIF by the HIF-1/SRC-3/CBP complex. Activation of MIF expression requires the binding of HRE by HIF-1α, which in turn recruits SRC-3 to the MIF promoter. Phosphorylation of S857 on SRC-3 by IKKα is required for the subsequent recruitment of CBP and eventual activation of MIF promoter. The ability of MIF to regulate autophagic cell death underscores its potential importance in cancer development.
