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. 2012 Jan 31;22(6):973–985. doi: 10.1038/cr.2012.18

Figure 7.

Figure 7

Model for reciprocal feedback regulation between MLH1 and miR-422a. MLH1 dimerizes with PMS2 to form MutLα in the cytoplasm, and the MutLα heterodimer then translocates into the nucleus to participate in genome maintenance via the MMR system. When MutLα reaches to a level that is toxic to cells, it begins to stimulate the conversion of pri-miR-422a into pre-miR-422a, leading to increasing production of pre-miR-422a and subsequently mature miR-422a. The resulting high level of mature miR-422a interacts with MLH1mRNA by pairing with a putative miR-422a interaction sequence in the MLH13′-UTR, which inhibits MLH1 translation.