Figure 2.

The balance analogy illustrates the relationship between AβDPs and net Aβ levels. By analogy with a balance, net Aβ concentrations (represented by the position of the pointer on the scale) are determined by the rate of Aβ production (represented by a single weight on one arm) relative to the overall rate of Aβ clearance (represented by a collection of counterweights on the other). Aβ clearance is performed by a collection of AβDPs (dark gray counterweights) working jointly with each other and with other eliminative processes (light gray counterweights). See text for additional details.