Table 1.

American Cancer Society (ACS) Criteria and Screening Recommendations for Individuals at Increased Risk Due to Family History

Cancer Type	Criteria for Family History	ACS Screening Recommendation	Criteria for Exclusion From Current Analysesa
Colorectal	≥1 FDR diagnosed before age 60 y or ≥2 FDRs diagnosed at any age	Colonoscopy every 5 y, starting at age 40 y or 10 y before youngest case in immediate family, whichever is earlier	History of polyposis; uterine cancer diagnosis
Breastb	≥1 FDR diagnosed before age 30 y or ≥1 FDR and ≥1 SDR diagnosed before age 60 y or ≥2 FDRs with 1 diagnosed before age 60 y and 1 diagnosed before age 70 y	Annual magnetic resonance imaging in addition to mammogram for women aged 35–60 y	Male; ovarian cancer diagnosis
Prostate	≥1 FDR diagnosed before age 65 y	Consider prostate-specific antigen blood test screening starting at age 45 y	Female

Abbreviations: FDR, first-degree relative; SDR, second-degree relative.

^aParticipants with cancer of interest were excluded from each analysis.

^bCriteria based on predicted lifetime breast cancer risk of at least 20% according to Claus tables.⁸