Table 4.
Results From Prospective Analyses: Rate of Change to High-Risk Screening Criteria During Follow-up (n = 1927)
| Cancer Type by Age at Enrollment, y |
Participants Without Family History at Enrollment |
Occurrences of Family History During Follow-up, No. |
10-Year Rate (95%CI)a |
|
|---|---|---|---|---|
| No. | Follow-up, y | |||
| Colorectal | ||||
| 18–29 | 72 | 511 | 0 | 0 (0–4) |
| 30–39 | 359 | 2444 | 4 | 2 (0–7) |
| 40–49 | 1102 | 8021 | 11 | 1 (0–6) |
| Overall | 1533 | 10 976 | 15 | 1 (0–6) |
| Breast | ||||
| 35–39 | 66 | 482 | 0 | 0 (0–4) |
| 40–49 | 223 | 1649 | 7 | 4 (1–10) |
| 50–59 | 328 | 2361 | 6 | 3 (0–9) |
| Overall | 617 | 4493 | 13 | 3 (0–9) |
| Prostate | ||||
| 18–29 | 18 | 134 | 1 | 7 (3–14) |
| 30–39 | 35 | 219 | 1 | 5 (2–12) |
| 40–49 | 110 | 782 | 2 | 3 (0–9) |
| Overall | 163 | 1135 | 4 | 4 (1–10) |
Abbreviation: CI, confidence interval.
a
The 10-year rate was calculated as the number of participants who newly met increased-risk criteria per 100 followed up for 10 years.