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Effects of VMY on cell cycle progression in human medulloblastoma cells. The human medulloblastoma cell lines (A), DAOY or (B) D556 were treated for 18 h with either LY294002 (LY), purvalanol B (PVB) or VMY at the concentrations shown. Cells were harvested and both DNA fragmentation (subG1) and the cell cycle profile were measured by flow cytometry. Data are average ± standard deviation of n ≥ three separate experiments vs. DMSO.
