Figure 1. PKC increases γ_MEAN of homomeric GluA1-L497Y AMPA receptors. (A) Representative macroscopic current response to 1 mM glutamate in an excised outside-out patch recorded under voltage clamp (V_HOLD = -60 mV). The upper trace shows the response after high pass filtering, illustrating the increase in membrane current noise during the response time course. (B) Current-variance relationship used to determine γ_MEAN for the trace shown in (A). (C) Summary of PKC effects on γ_MEAN of GluA1-LY AMPA receptors expressed in the presence of stargazin in HEK293T cells. *p < 0.001 by Student’s t-test. Data are from 8–14 outside-out patches for each condition.