Figure 2.

Conserved elements in eukaryotic porins. Euglenozoa sequences from the composite MSA of eukaryotic porins are shown. For each sequence the region is shown, which aligns most frequently to the helical region (left) and to the last β-strand (right) of the crystal structure of mVDAC-1. Amino acids are coloured with Jalview (Clustalx colour code), reflecting the conservation of the respective alignment column. On the bottom conserved properties derived from the MSA of VDAC [5] and the β-signal definition [19,20] are displayed: polar (p), aromatic (a), glycine (G), hydrophobic (h), positive (plus symbol), negative charge (minus symbol).