Table 1.
List of companies with Amyotrophic Lateral Sclerosis therapeutic relevant strategies, their location and targets
| Company | Location | Target |
|---|---|---|
| Acetylon | US- Massachusetts | Protein aggregation |
| ALS Biopharma | US-Pennsylvania | Protein aggregation |
| ALS Therapy Development Institute | US-Massachusetts | Inflammation |
| Amarantus Therapeutics | US-California | Growth factor |
| Amorfix | Canada | Vaccine |
| Brainstorm Cell Therapeutics | US-New York and Israel | Stem cells |
| Braintact | Israel | Excitotoxicity |
| Cambria | US-Massachusetts | Protein aggregation |
| Chaperone Therapeutics | US-North Carolina | Protein aggregation |
| Cognosci | US-North Carolina | Inflammation |
| Cytokinetics | US-California | Muscle contractility |
| Daval International | UK | Inflammation |
| Debiopharm Group / Curis Inc | Switzerland / US- Massachusetts | Protein aggregation |
| Enkam | Denmark | Growth factor |
| EnVivo Pharmaceuticals | US- Massachusetts | Protein aggregation |
| ExonHit Therapeutics/Allergan | France | Protein aggregation |
| Fate Therapeutics | US-California | Stem cells |
| FoldRx | US- Massachusetts | Protein aggregation |
| Genervon Biopharmaceuticals | US-California | Growth factors |
| GenKyoTex | Switzerland | Oxidative stress |
| Isis Pharmaceuticals | US-California | RNA strategies |
| Knopp Biosciences/Biogen | US-Pennsylvania, Massachusetts | Oxidative stress |
| miRagen Therapeutics | US-Colorado | RNA strategies |
| NeuralStem | US-Maryland | Stem cells |
| Neurimmune Therapeutics | Switzerland | Vaccine |
| Neurogeneration | US-California | Stem cells |
| NeuroNascent, Inc | US-Maryland | Stem cells |
| NeuroNova | Sweden | Growth factor |
| NeuroPhage | US- Massachusetts and Israel | Protein aggregation |
| NexGenix Pharmaceuticals | US-New York | Protein aggregation |
| Oxford Biomedica | UK | Growth factor |
| PharmaTrophix | US-North Carolina | Growth factor |
| Phytopharm | UK | Growth factor |
| Pluristem Therapeutics | Israel | Stem cells |
| Proteostasis | US- Massachusetts | Protein aggregation |
| Q Therapeutics | US-Utah | Stem cells |
| Reata Pharmaceuticals | US-Texas | Protein aggregation |
| ReNeuron | UK | Stem cells |
| Repligen Corporation | US- Massachusetts | Protein aggregation |
| Retrotope, Inc | US-California | Oxidative stress |
| RhinoCyte | US-Kentucky | Stem cells |
| RXi Pharmaceuticals | US- Massachusetts | RNA strategies |
| Samaritan Pharmaceuticals | US-Nevada | Stem cells |
| SanBio | US-California | Stem cells |
| Saneron | US-Florida | Stem cells |
| ShanaRx | US-California | Growth Factors |
| Sirtris/GSK | US- Massachusetts | Protein aggregation |
| Stealth Peptides | US-Maryland | Oxidative stress |
| StemCells | US-California and UK | Stem cells |
| Takeda | Japan | Oxidative stress |
| Transition Therapeutics | Canada | Inflammation |
| Trophos | France | Oxidative stress |
| Varinel | Israel | Iron chelation |
| Vasopharm | Germany | Oxidative stress |
| ZZ Biotech | US-New York | Inflammation |